AOD 9604

Key Takeaways of AOD 9604

AOD 9604 is believed to facilitate fat loss by stimulating the breakdown of fat cells and inhibiting the formation of new fat cells. It primarily targets stubborn and visceral fat, making it a potential tool for weight management.
AOD 9604 is a modified form of amino acids 176-191 from the human growth hormone (HGH). Its structure makes it more specific in targeting fat cells while having minimal impact on other bodily functions.
Unlike full-length hGH, AOD 9604 has minimal impact on increasing muscle mass or affecting bone growth. This makes it a potentially safer option for weight loss without the growth-promoting effects of hGH.
AOD 9604 is generally considered safe with few reported side effects. It doesn’t affect insulin sensitivity or blood glucose levels significantly, making it a potentially safer option for weight loss compared to other compounds.
When combined with other weight loss strategies such as diet and exercise, AOD 9604 may offer synergistic effects, further supporting weight loss efforts. If considering AOD-9604 for weight management, it’s crucial to consult a healthcare professional for guidance and monitoring.

Potential Benefits of AOD 9604

AOD 9604 offers primary benefits such as promoting weight loss and treating osteoarthritis, contributing to an overall enhancement in health.

Helps lose weight [1-10]
Treats osteoarthritis [11-12]

What is AOD 9604 Peptide?

Anti-Obesity Drug-9604 (AOD 9604 or AOD-9604) is a synthetic analog of the human growth hormone. Its main purpose is to fight obesity and help people trying to lose weight. This anti-obesity drug works by stimulating the pituitary gland and other hormones to speed up the body’s metabolism, resulting in faster weight loss.

How AOD 9604 Works

AOD 9604 works by stimulating the body’s natural fat-burning process known as lipolysis. Lipolysis is the biological process of breaking down triglycerides (fats) stored in adipose tissue (fat cells) into their constituent components, namely glycerol and fatty acids. This process provides energy for the body when needed.

Here’s a step-by-step explanation of the lipolysis process:

Stimulation: Lipolysis is typically initiated when the body requires energy, and signals are sent to activate the process. This can happen for various reasons, such as during exercise, fasting, or when the body needs an additional energy source. In some cases, certain hormones that stimulate the pituitary gland can also influence metabolic processes, including lipolysis. One of the primary objectives of lipolysis is to burn fat and convert it into usable energy. Engaging in activities that stimulate lipolysis, or even those that stimulate the pituitary gland to release growth-promoting hormones, can be an effective way to burn fat and achieve a leaner physique.
Hormonal Regulation: Hormones play a critical role in regulating lipolysis and the breakdown of body fat. The primary hormone responsible for stimulating lipolysis and the subsequent release of stored body fat for energy is epinephrine (adrenaline), which is released by the adrenal glands in response to stress or other triggers. Additionally, other hormones like norepinephrine, cortisol, and glucagon also contribute to the activation of lipolysis, further assisting in the mobilization of body fat for energy production.
Receptor Activation: Once these hormones are released into the bloodstream, they bind to specific receptors on the surface of fat cells, known as adipocytes. In particular, they interact with beta-adrenergic receptors.
Activation of Adenylate Cyclase: The binding of hormones to these receptors activates an enzyme called adenylate cyclase located within the fat cell. This enzyme plays a crucial role, especially in cells with high levels of fat. Adenylate cyclase converts adenosine triphosphate (ATP) into cyclic adenosine monophosphate (cAMP), facilitating the mobilization and utilization of stored fat.
cAMP Signaling: cAMP acts as a second messenger within the cell and activates an enzyme called protein kinase A (PKA). In the context of weight loss research, PKA plays a crucial role in the action of the fat-burning peptide AOD 9604. The introduction of a fat-burning peptide can elevate cAMP levels, further enhancing the activity of PKA and promoting the breakdown of stored fats.
PKA Activation: PKA phosphorylates (adds phosphate groups) to several enzymes involved in lipolysis, including hormone-sensitive lipase (HSL) and perilipin. HSL is a key enzyme responsible for breaking down triglycerides into glycerol and fatty acids.
HSL Action: Activated HSL begins to hydrolyze the triglycerides stored in lipid droplets within the fat cell. This hydrolysis breaks the chemical bonds between the glycerol and fatty acids.
Release of Glycerol and Fatty Acids: Once HSL completes its action, it releases glycerol and fatty acids into the bloodstream. Glycerol can be used as an energy source by various tissues, including the liver. Fatty acids are transported through the bloodstream bound to proteins called albumin to reach other tissues, where they are used as an energy source.
Energy Production: In tissues such as muscle cells, the mitochondria oxidize fatty acids, often derived from the consumption of fatty foods, through beta-oxidation to generate adenosine triphosphate (ATP), the body’s primary energy currency.
Glycerol Utilization: The glycerol released during lipolysis can undergo glycolysis in the liver to produce ATP or can be converted into glucose via gluconeogenesis if needed for energy.
Feedback Regulation: As the body’s energy needs change, lipolysis is tightly regulated through feedback mechanisms. When energy needs decrease, insulin, among other hormones, can inhibit lipolysis and promote fat storage. It’s beneficial during these times to consider incorporating non-fatty foods into one’s diet to further manage and balance energy storage and expenditure.

Research on AOD 9604

A. Help Lose Weight

AOD 9604, a synthetic peptide derived from the C-terminus of human growth hormone, is believed to promote weight loss by enhancing fat metabolism. Through a medical weight loss program, individuals seeking greater weight loss might be introduced to solutions like AOD 9604. Unlike the full-length growth hormone, AOD 9604 specifically targets fat cells, stimulating the breakdown of fat (lipolysis) and inhibiting the formation of new fat (lipogenesis). This makes it a promising candidate for those enrolled in a medical weight loss program aiming for a healthy weight.

Additionally, it doesn’t have adverse effects on blood sugar or tissue growth commonly associated with growth hormones. By integrating AOD 9604 peptide into a medical weight loss strategy, there’s potential for more significant weight loss, offering a focused approach to reducing body fat more effectively.

A number of high-quality studies suggest that AOD 9604 peptide has potent fat-burning properties necessary for medical weight loss:

In obese rats, supplementation with a daily dose of oral AOD 9604 resulted in significant fat-burning effects. [1]
In obese mice, AOD 9604 treatment greatly reduced weight gain by stimulating fat oxidation. [2]
A study showed that AOD 9604 peptide has fat-burning activities in the body. [3]
In obese mice, AOD 9604 treatment was associated with increased fat oxidation, reduced body weight gain, and increased lipolysis (fat breakdown). [4]
A study showed that AOD 9604 treatment safely produced the same weight reduction benefits as HCG but without adverse effects. [5-6]
A review of several studies on obesity treatment found that oral AOD 9604 is safe and effective for weight loss without any adverse effects on blood sugar levels. [7]
In obese patients, daily administration of AOD 9604 peptide for 12 weeks resulted in significant weight loss. [8]
In overweight patients with metabolic risk factors, AOD 9604 was shown to be an effective weight loss drug. [9]
A 12-week phase II study showed that patients who received a low-dose (1 mg) oral AOD 9604 peptide exhibited significant weight loss compared with patients who received placebo treatment. [10]

B. Treats Osteoarthritis

AOD 9604 peptide has been studied not only for its potential weight loss benefits but also for its potential therapeutic effects on osteoarthritis and other bone disorders. The peptide is believed to promote cartilage regeneration and enhance collagen production, both vital for joint health, bone strength, and cartilage and bone repair. In the context of osteoarthritis, where cartilage degeneration occurs, AOD 9604 might help slow down this degeneration and possibly reverse some of the damage by promoting cartilage repair and aiding in cartilage and bone repair processes.

The potential of AOD 9604 in bone repair makes it a promising candidate for broader therapeutic applications. While promising, it’s essential to note that more comprehensive clinical trials and research are required to fully ascertain its efficacy and safety in promoting bone repair and treating osteoarthritis and other bone-related conditions.

AOD 9604 peptide has also been found to have regenerative properties that are essential for optimum bone health:

In osteoarthritis (OA) rabbit models, multiple injections of combined AOD 9604 and hyaluronic acid resulted in faster cartilage regeneration. [11]
In rats that had surgical removal of the ovaries, AOD 9604 pill treatment greatly increased bone mineral density and offered protective effects against osteoporosis. [12]

AOD 9604 Side Effects

AOD 9604 side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the patient had one of the issues listed below at some point while being on AOD 9604. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of AOD 9604. Despite this, it was listed as a side effect associated with AOD 9604 even though these associated side effects are very uncommon.

Side effects associated with AOD 9604 may include the following:

Diarrhea
Flatulence
Increased appetite
Mild or moderate headache
Nausea

AOD 9604 Dosage

Here’s a general breakdown of its dosage:

Standard Dosage: Common dosages in anecdotal reports and some studies range from 250 to 500 micrograms per day. The peptide is often administered via subcutaneous injection, which means it’s injected into the fatty layer just below the skin. Depending on the recommendation, some users might split this dose into two, typically a morning and evening AOD 9604 injection.
Duration of Treatment: The duration for which AOD 9604 should be taken can vary based on individual goals and responses. Some users and studies have suggested treatment durations ranging from 6-8 weeks or longer.
Combination with Other Peptides: Sometimes, AOD 9604 is used in combination with other peptides or compounds to potentially enhance results, including optimizing calorie burn. However, combining substances can also increase the risk of side effects, so it’s vital to approach this with caution. Understanding how each component influences metabolism and calorie burn can offer a more comprehensive perspective on potential outcomes and risks.

It’s important to stress that before starting AOD 9604 or any other peptide therapy, individuals should consult with a healthcare provider. This is essential to ensure that the peptide is appropriate for their specific circumstances, to confirm dosing guidelines, and to receive proper dosage instructions, which might include storing the peptide at a cool temperature or guidance on how it interacts with other injections. Adhering to these instructions can prevent potential adverse reactions. Furthermore, storing peptides like AOD 9604 at the recommended cool temperature can ensure its efficacy and longevity. Regular consultation allows for monitoring any side effects and adjusting treatment as necessary, especially when combined with other injections or medications.

AOD 9604 Before and After

AOD 9604, a synthetic peptide derived from human growth hormone, has garnered attention for its potential role in promoting fat metabolism and weight loss. Before starting the treatment, many individuals seeking weight management solutions often find themselves struggling with persistent fat pockets despite adhering to a regular exercise routine and a healthy diet such as a lower-calorie diet. They might experience slow metabolism and find it challenging to shed those extra pounds.

After several weeks to months of AOD 9604 administration, some users report noticeable changes. There’s often a reduction in stubborn fat areas, an uptick in metabolic rates, and, in some instances, overall weight loss. Enhanced energy levels and an improved sense of well-being are also anecdotal outcomes associated with the peptide. However, it’s essential to note that individual results can vary greatly. While some might observe significant changes, others might experience subtler shifts.

Additionally, the effectiveness of AOD 9604 can be influenced by factors like diet, exercise routines, and individual physiological responses such as the body’s metabolism. To see results, it’s crucial to maintain a balanced approach and make necessary adjustments based on how one’s body reacts. Some users might experience side effects, highlighting the importance of monitoring and consultation with healthcare professionals. This ensures safety and efficacy in one’s journey with AOD 9604.

AOD 9604 vs Semaglutide

AOD 9604 and semaglutide are both substances that have been researched for their potential effects on weight management, but they function through different mechanisms and have different primary purposes. Here’s a comparison:

AOD 9604

Nature: A synthetic peptide derived from the C-terminus of human growth hormone.
Mechanism of Action: It’s believed to stimulate fat metabolism without having significant effects on blood sugar levels or promoting tissue growth.
Primary Use: Mainly researched for its potential fat metabolism properties and weight loss benefits.

Semaglutide

Nature: A glucagon-like peptide-1 (GLP-1) receptor agonist.
Mechanism of Action: GLP-1 receptor agonists work by mimicking the functions of the body’s natural GLP-1. They can decrease appetite and food intake, slow down the emptying of the stomach, and increase insulin production, thus helping in blood sugar management.
Primary Use: Initially developed to treat type 2 diabetes, but recent studies have shown its potential in weight management. The weight loss formulation, often referred to under the brand name Wegovy, has been approved by the FDA for chronic weight management.

While both AOD 9604 and semaglutide have implications in weight management, they are distinct in their modes of action and approval status. Semaglutide has robust clinical data supporting its efficacy and safety in weight management, and it’s approved for such use. In contrast, AOD 9604 is still in the realm of research and anecdotal evidence, with its safety and efficacy yet to be conclusively determined.
Before considering either for weight management, it’s crucial to consult with a healthcare professional to understand potential risks, benefits, and to determine which, if any, is suitable for individual circumstances.

Reference

Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. doi: 10.1159/000053183. PMID: 11146367.
Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9. doi: 10.1038/sj.ijo.0801740. PMID: 11673763.
Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
Available at https://www.researchgate.net/publication/11678445_Increase_of_fat_oxidation_and_weight_loss_in_obese_mice_caused_by_chronic_treatment_with_human_growth_hormone_or_a_modified_C-terminal_fragment.
Available at https://journals.physiology.org/doi/full/10.1152/ajpendo.2000.279.3.E501.
Judith Korner, Louis J. Aronne, Pharmacological Approaches to Weight Reduction: Therapeutic Targets, The Journal of Clinical Endocrinology & Metabolism, Volume 89, Issue 6, 1 June 2004, Pages 2616–2621, https://doi.org/10.1210/jc.2004-0341.
Misra M. Obesity pharmacotherapy: current perspectives and future directions. Curr Cardiol Rev. 2013;9(1):33-54. doi:10.2174/157340313805076322.
Available from https://www.news-medical.net/news/2004/12/16/6878.aspx.
Available from https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2006.294.
Herd, C., Wittert, G., Caterson, I., et al. The effect of AOD9604 on weight loss in obese adults: results of a randomized, double-blind, placebo-controlled, multicenter study 2005 Annual Scientific Meeting of the North American Association for the Study of Obesity, October 18, 2005, Vancouver, British Columbia, Canada.
Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
Gu F, Jiang J, Wang S, et al. An experimental research into the potential therapeutic effects of Anti-Osteoporosis Decoction and Yougui Pill on ovariectomy-induced osteoporosis. Am J Transl Res. 2019;11(9):6032-6039. Published 2019 Sep 15.