Epithalon

Reverses Signs of Aging

Compelling evidence suggests that the administration of epithalon can increase life span and reverse signs of aging:

1. It was concluded that the administration of the synthetic peptide epithalon might overcome genetic limitations and normalize body functions. [1]
2. Epithalon has been found to fight signs of aging through its immunomodulatory properties, an integral function of the immune system. [2]
3. A study was made on rats that showed epithalon administration resulted in increased melatonin production, improved immunological parameters, enhanced antioxidant defenses, and restoration of reproductive function. [3]
4. Circadian rhythms of melatonin and cortisol production in old rhesus monkeys were also restored. [4]
5. Epithalon was found to stimulate the release of melatonin in older people, which resulted in a deeper sleep. [5]
6. It also showed to improve complications with Alzheimer’s disease, amyotrophic lateral sclerosis, jet lag, and nocturnal hypertension. [6]
7. In aging monkeys, epithalon stimulated evening melatonin secretion and reestablished the circadian rhythm associated with cortisol release. [7]
8. Common fruit flies exposed to epithalon during their developmental stage showed an increased lifespan from 11-16%. [8]
9. Epithalon showed a substantial decrease in the extent of memory disorders in old rats. [9]
10. There is a study done on chicks that suggest that epithalamin stimulates the growth of brain and spinal nerves. [10]
11. Epithalon has been shown to promote an increase in lymphocytes from the thymus of elderly people, thus improving immune function in the specific age group. [11]
12. In female mice, epithalon improved biomarkers of aging and life span. [12-13]
13. Epithalon was found to have more benefits than melatonin as it also stimulates superoxide dismutase (SOD), ceruplasmin, and other antioxidant enzymes. [14]
14. In male rats, epithalamin increased total antioxidant capacity by 36% and superoxide dismutase (a powerful antioxidant) by 19%. [15]
15. Because of its ability to stimulate melatonin production and mechanisms related to melatonin, epithalon’s antioxidant benefits were also proven. [16]

Prevents and Treats Cancer

One of the diseases caused by oxidative stress or free radical damage is cancer. Studies suggest that epithalon’s ability to increase the body’s antioxidant capacity can also help with slowing cancer growth:

1. In female spontaneously hypertensive rats (SHR), epithalon injection inhibited the development of leukemia. [12]
2. In female transgenic mice, epithalon administration inhibited the development of breast cancer. [17]
3. In rats, continued epithalon administration throughout the experiment resulted in a significant inhibitory effect against colon cancer. [18]
4. In mice, epithalon slowed and inhibited the spread of tumors. [19]
5. When epithalon was given to rats with colon cancer, the peptide increased lymph flow (containing white blood cells) and apoptosis (programmed cell death), while it slowed cancer growth. [20]
6. In mice with mammary tumors, epithalon significantly decreased the number of mice with multiple tumors and decreased the maximum size of tumors compared to control mice. [21]
7. A study in mice found that treatment with epithalon reduced the number of mice with malignant tumors (cancerous tumors) and prevented cancer from metastasizing (moving to another location in the body) in all of the treated mice. [22]

Prevents Cardiovascular Disease

Studies suggest that epithalon can help reduce the risk of heart disease by improving various health parameters:

1. A study showed that the ability of epithalon to preserve telomere length can help prevent cardiovascular disease. [23]
2. In middle-aged and elderly women, epithalon supplementation greatly reduced the occurrence of ischemic heart disease. [24]
3. A study showed that elder women treated with epithalamin had improved lipid metabolism, which eventually led to a reduction in arterial blood pressure. [25]
4. Epithalamin was also shown to improve functional stability and quality of cardiovascular system regulation, showing improvement in blood flow of the patients treated. [26]

Boosts Brain Health

Evidence also suggests that epithalon is integral for maintaining normal cognitive function:

1. Epithalon showed a substantial decrease in the extent of memory disorders in old rats. [9]
2. A study showed that epithalon plays a role in the formation of new neurons in the brain. [27]
3. In rats, intranasal administration of epithalon resulted in significant activation of neuronal activities. [28]
4. In male rats, intranasal administration of epithalon triggered the neurons to become more active. [29]

Promotes Quality Sleep

Studies suggest that the ability of epithalon to regulate the production of the sleep hormone melatonin can help promote quality sleep:

1. In older people, epithalon was found to stimulate the release of melatonin, which resulted in a deeper sleep. [5]
2. In old female monkeys, epithalon greatly stimulated melatonin synthesis which is important for good sleep. [7]
3. In old monkeys, epithalon treatment was found to be effective in treating age-related hormonal imbalance by inducing increased melatonin production. [30]
4. In old monkeys and elderly people, epithalon induced safe regulation of blood melatonin levels without any side effects. [31]
5. In healthy elderly patients, epithalon treatment initiated the melatonin-producing function of the pineal gland which in turn improved sleep quality. [32]

Improves Eye Health

Evidence also found that epithalon can help combat age-related decline in eye function and other eye disorders:

1. In rats, epithalon administration resulted in improved retinal functionality and preserved its structure. [33-35]
2. A study showed that epithalon stimulated the proliferation of retinal and pigmented epithelial cells. [36]
3. In patients with degenerative retinal lesions, epithalon therapy produced beneficial effects on visual function. [37]

Boosts Immunity

Studies also show that epithalon has immune-boosting properties:

1. In aging mice, it was shown that epithalon could increase T-cell production. [11]
2. In chickens, epithalon injections effectively treated humoral immune deficiency. [38-39]
3. In adult and old mice, epithalon administration increased the levels of immune system cells such as CD3+, CD4+CD8-, CD4-CD8+, and Mac-1(+)-. [40]
4. In old rats, epithalon played a role in regulating immunity by maintaining optimal spleen function. [41]

Treats Symptoms of Diabetes

There are also studies supporting the beneficial effects of epithalon on blood sugar and diabetic symptoms:

1. In female rhesus monkeys of various ages, epithalon restored the insulin level in response to a glucose load. [42]
2. In non-insulin-dependent (Type 2) diabetics, epithalamin treatment improved carbohydrate metabolism and insulin sensitivity. [43]
3. Diabetic retinopathy (eye complication of diabetes) was also improved with epithalon administration in diabetic patients. [44]
4. In young and old rats, epithalon increased protein and sugar digestion. [45]