MOTS-C 10mg

“Purity: >98% (HPLC on request) | Molecular Formula: C101H152N28022S2. C2HF302. Molecular Weight: 2288.6 g/mol | Sequence: MRWQEMGYIFYPRKLR”

10mg/ml solution provided in a 4ml vial.

“The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated.
The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA. Here we report a sORF within the mitochondrial 125 RNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation. MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
These results suggest that I mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome. that regulates insulin sensitivity and metabolic Lee, Changhan & Zeng, Jennifer & G. Drew, Brian & Sallam, Tamer & Martin-Montalvo, Alejandro & Wan, Junxiang & Kim, Su-Jeong & Mehta, Hemal & Hevener, Andrea & Cabo, Rafael & Cohen, Pinchas. (2015). The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Keduces Obesity and Insulin Kesistance. Cell metabolism. 21. 443-494.”