MOTS-C 10mg
$165.00 Original price was: $165.00.$115.00Current price is: $115.00.
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- Physical profile: Lyophilized powder
- This product is sold as a research chemical and not for human or animal consumption. For laboratory use by qualified professionals.
Availability: 8 in stock
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This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabled as a drug, food or cosmetic.
The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA. Here we report a sORF within the mitochondrial 125 RNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation. MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
These results suggest that I mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome. that regulates insulin sensitivity and metabolic Lee, Changhan & Zeng, Jennifer & G. Drew, Brian & Sallam, Tamer & Martin-Montalvo, Alejandro & Wan, Junxiang & Kim, Su-Jeong & Mehta, Hemal & Hevener, Andrea & Cabo, Rafael & Cohen, Pinchas. (2015). The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Keduces Obesity and Insulin Kesistance. Cell metabolism. 21. 443-494.”
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