TB500 (Thymosin B4 Acetate) 5mg

“Purity: >98% (HPLC on request) | Molecular Formula : C212H350N560785 Molecular Weight: 4963.506 g/mol | Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-lle-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys Thr-Glu-Thr-Gin-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thy-lleGlu-Gin-Glu-Lys-Gin-Ala-Gly-Glu-Ser”

3000mcg/ml subcutaneous injection provided in a 5ml vial.

“Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.
A cDNA clone encoding human thymosin-beta 4 was blot analyses of different neoplastic B lymphocytes revealed isolated from a cDNA library prepared from peripheral that steady state levels of thymosin-beta 4 mRNA varid as a blood leukocytes of a patient with acute lymphocytic function of differentiation stage. Thymosin-beta 4 mRNA leukemia. This clone contained the entire coding sequence levels were decreased in myeloma cells as are class II of 43 amino acid residues of thymosin-beta 4 and had an human leukocyte antigen, Fc receptor, and complement initiation codon and two termination codons. The amino receptor, suggesting a relationship between thymosin-beta acid and nucleotide sequences in the coding region were 4 and the immune response. Thymosin-beta 4 mRNA well conserved between rat and human. Nine of 132 was more highly expressed in mature granulocytes than in nucleotides were different in the coding sequences (93% immature blastic cells. Treatment of THP-1 cells, a human homology), but the deduced amino acid sequences were monocytic cell line, with recombinant human interferonidentical.
No signal peptide was found in the deduced lambda reduced the levels of thymosin-beta 4 mRNA. Its protein sequence. Human thymosin-beta 4 mRNA, level decreased after differentiation of THP-1 cells into la+ approximately 830 nucleotides in length, was about 30 macrophages, but increased after differentiation of HL-60 nucleotides larger than rat thymosin-beta 4 mRNA. cells into la- macrophages. The pattern of thymosin-beta Expression of the human thymosin-beta 4 gene in various 4 gene expression suggests that it may play a fundamental primary myeloid and lymphoid malignant cells and in a role in the host defense mechanism. few human hemopoietic cell lines was studied. Northern H Gondo, J Kudo, J W White, C Barr, P Selvanayagam, G F Saunders The Journal of Immunology December 1, 1987, 139 (11) 3840-3848;”